Polynucleotide therapy

Description

At Stoimenov Dermatology, we apply the most advanced protocols for natural skin rejuvenation through injection therapy with polynucleotides (PDRN) – an innovative group of bioactive molecules that activate the skin's natural repair mechanisms.

We use two of the most effective products on the market – Pluryal® SILK and Pluryal® DENSIFY, produced using patented HPN technology from salmon DNA of exceptional purity.

What are the indications?

Polynucleotides are fragments of DNA that:

• Stimulate fibroblasts to produce new collagen and elastin
• Thin, sagging and tired skin
• Improves cellular hydration by binding water
• Activates DNA repair and cellular repair mechanisms
• They have strong antioxidant and anti-inflammatory effects
• Improves microcirculation and oxygenation in the skin

Why choose Pluryal® SILK and DENSIFY?

• SILK – delicate formula for the eye contour and eye area.
• DENSIFY – a combination of polynucleotides + hyaluronic acid + mannitol – suitable for the entire face, décolleté, neck and more
• Clinically proven effect – Pluryal Densify rejuvenates the skin by up to 7 years (VISIA study)
• Higher efficacy than comparable products, proven in ex-vivo and in-vitro tests
• High safety – 100% biodegradable, without the risk of granulomas or Tyndall effect.

What are the indications?

• Fine lines, wrinkles, dehydration.
• Loss of density and tone
• Acne scars, enlarged pores, stretch marks
• Dark circles and sagging around the eyes
• Redness, erythema, unbalanced skin
• Preparation and maintenance after other aesthetic procedures

Composition and technologies

PLURYAL SILK

• 15 mg polynucleotides / 2 ml
• For eye contour, lips, neck, stretch marks
• Proven to increase collagen density in the dermis by +7%
• Higher efficacy than comparable products, proven in ex-vivo and in-vitro tests
• High safety – 100% biodegradable, without the risk of granulomas or Tyndall effect.

Pluryal® DENSIFY

• 20 mg PN + 20 mg HA + 80 mg mannitol
• For face, neck, décolleté (mature skin)
• Stimulates the synthesis of collagen I, III, elastin, HAS-1 and fibronectin

Therapy protocol

• Initially: 2-3 treatments every 2-6 weeks
• Maintenance therapy: every 4–6 months
• Results: noticeable after the first procedure, with progressive improvement

Scientifically proven effectiveness

• +38% collagen type I
• +25% elastin
• +59% increased hydration in the epidermis
• +24% collagen type III
• Improves cell viability and dermal structure (ex-vivo tests)

„"Polynucleotides are the heart of regenerative medicine. They don't just repair – they reboot the skin."“